Bleach 43 - The Despicable Shinigami

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Credit for summary: Wikipedia

Orihime and Uryu continue towards Rukia's location, but are accosted by Makizo Aramaki, a Soul Reaper of the eleventh division. Some twelfth division members arrive to help, but Mayuri, who has made them into human bombs, detonates them. Orihime uses her powers to protect Uryu and herself from the explosions, and Mayuri expresses his wish to experiment on Orihime. Uryu begins to fight Mayuri, but is quickly disabled by the paralyzing abilities of Mayuri's zanpakuto when his lieutenant, Nemu Kurotsuchi, uses her body to hold down Uryu. Mayuri then reveals that he has experimented on many other Quincy, including Uryu's grandfather, Soken Ishida, and was responsible for his death.